Olimel N9E/PeriOlimel N4E

Olimel N9E Per 1,000 mL Refined olive oil + refined soy bean oil 40 g, alanine 8.24 g, arginine 5.58 g, aspartic acid 1.65 g, glutamic acid 2.84 g, glycine 3.95 g, histidine 3.4 g, isoleucine 2.84 g, leucine 3.95 g, lysine 4.48 g (lysine acetate 6.32 g), methionine 2.84 g, phenylalanine 3.95 g, proline 3.4 g, serine 2.25 g, threonine 2.84 g, tryptophan 0.95 g, tyrosine 0.15 g, valine 3.64 g, Na acetate trihydrate 1.5 g, hydrated Na glycerophosphate 3.67 g, KCl 2.24 g, Mg chloride hexahydrate 0.81 g, Ca chloride dihydrate 0.52 g, glucose anhydrous 110 g (glucose monohydrate 121 g). Per 1,500 mL Refined olive oil + refined soy bean oil 60 g, alanine 12.36 g, arginine 8.37 g, aspartic acid 2.47 g, glutamic acid 4.27 g, glycine 5.92 g, histidine 5.09 g, isoleucine 4.27 g, leucine 5.92 g, lysine 6.72 g (lysine acetate 9.48 g), methionine 4.27 g, phenylalanine 5.92 g, proline 5.09 g, serine 3.37 g, threonine 4.27 g, tryptophan 1.42 g, tyrosine 0.22 g, valine 5.47 g, Na acetate trihydrate 2.24 g, hydrated Na glycerophosphate 5.51 g, KCl 3.35 g, Mg chloride hexahydrate 1.22 g, Ca chloride dihydrate 0.77 g, glucose anhydrous 165 g (glucose monohydrate 181.5 g). Per 2,000 mL Refined olive oil + refined soy bean oil 80 g, alanine 16.48 g, arginine 11.16 g, aspartic acid 3.3 g, glutamic acid 5.69 g, glycine 7.9 g, histidine 6.79 g, isoleucine 5.69 g, leucine 7.9 g, lysine 8.96 g (lysine acetate 12.64 g), methionine 5.69 g, phenylalanine 7.9 g, proline 6.79 g, serine 4.5 g, threonine 5.69 g, tryptophan 1.9 g, tyrosine 0.3 g, valine 7.29 g, Na acetate trihydrate 2.99 g, hydrated Na glycerophosphate 7.34 g, KCl 4.47 g, Mg chloride hexahydrate 1.62 g, Ca chloride dihydrate 1.03 g, glucose anhydrous 220 g (glucose monohydrate 242 g). PeriOlimel N4E Per 1,500 mL Refined olive oil + refined soya bean oil 45 g, alanine 5.5 g, arginine 3.72 g, aspartic acid 1.1 g, glutamic acid 1.9 g, glycine 2.63 g, histidine 2.26 g, isoleucine 1.9 g, leucine 2.63 g, lysine 2.99 g (lysine acetate 4.21 g), methionine 1.9 g, phenylalanine 2.63 g, proline 2.26 g, serine 1.5 g, threonine 1.9 g, tryptophan 0.64 g, tyrosine 0.1 g, valine 2.43 g, Na acetate trihydrate 1.73 g, hydrated Na glycerophosphate 2.87 g, KCl 1.79 g, Mg chloride hexahydrate 0.67 g, Ca chloride dihydrate 0.44 g, glucose anhydrous 112.5 g (glucose monohydrate 123.75 g). Per 2,000 mL Refined olive oil + refined soya bean oil 60 g, alanine 7.33 g, arginine 4.96 g, aspartic acid 1.46 g, glutamic acid 2.53 g, glycine 3.51 g, histidine 3.02 g, isoleucine 2.53 g, leucine 3.51 g, lysine 3.98 g (lysine acetate 5.62 g), methionine 2.53 g, phenylalanine 3.51 g, proline 3.02 g, serine 2 g, threonine 2.53 g, tryptophan 0.85 g, tyrosine 0.13 g, valine 3.24 g, Na acetate trihydrate 2.31 g, hydrated Na glycerophosphate 3.82 g, KCl 2.38 g, Mg chloride hexahydrate 0.9 g, Ca chloride dihydrate 0.59 g, glucose anhydrous 150 g (glucose monohydrate 165 g)

Parenteral nutrition for adults & childn >2 yr when oral or enteral nutrition is impossible, insufficient or contraindicated.

Olimel N9E Individualised dosage. Administered through a central vein. Adult Max daily dose is defined by amino acids intake, 35 mL/kg (corresponding to 2 g/kg amino acids, 3.9 g/kg glucose, 1.4 g/kg lipids, 1.2 mmol/kg Na & 1.1 mmol/kg K). Max infusion rate: 1.8 mL/kg/hr, corresponding to 0.1 g/kg/hr amino acids, 0.19 g/kg/hr glucose, 0.07 g/kg/hr lipids. Childn 12-18 yr Limiting factors: Phosphate conc (0.2 mmol/kg/day) for daily dose; amino acid conc for hrly rate. Max daily dose: 50-80 mL/kg fluids, 1-2 g/kg amino acids, 3-10 g/kg (up to 14) glucose, 0.5-2 g/kg (up to 3) lipids. Max infusion rate: 2.1 mL/kg/hr, 2-11 yr Limiting factors: Phosphate conc (0.2 mmol/kg/day) for daily dose; lipid conc for hrly rate. Max daily dose: 60-120 mL/kg fluids, 1-2 g/kg (up to 3) amino acids, 12-14 g/kg (up to 18) glucose, 0.5-3 g/kg lipids. Max infusion rate: 3.3 mL/kg/hr. PeriOlimel N4E Individualised dosage. Administered through a peripheral or central vein. Adult Max daily dose is defined by fluid intake, 40 mL/kg (corresponding to 1 g/kg amino acids, 3 g/kg glucose, 1.2 g/kg lipids, 0.8 mmol/kg Na & 0.6 mmol/kg K). Max infusion rate: 3.2 mL/kg/hr, corresponding to 0.08 g/kg/hr amino acids, 0.24 g/kg/hr glucose, 0.1 g/kg/hr lipids. Childn 12-18 yr Limiting factors: Phosphate conc (0.2 mmol/kg/day) for daily dose; lipid conc for hrly rate. Max daily dose: 50-80 mL/kg fluids, 1-2 g/kg amino acids, 3-10 g/kg (up to 14) glucose, 0.5-2 g/kg (up to 3) lipids. Max infusion rate: 4.3 mL/kg/hr, 2-11 yr Limiting factors: Phosphate conc (0.2 mmol/kg/day) for daily dose; lipid conc for hrly rate. Max daily dose: 60-120 mL/kg fluids, 1-2 g/kg (up to 3) amino acids, 12-14 g/kg (up to 18) glucose, 0.5-3 g/kg lipids. Max infusion rate: 4.3 mL/kg/hr.

Hypersensitivity to egg, soybean, or peanut proteins, or to any of the active substances or excipients of the formulation. Congenital abnormalities of amino acid metabolism. Severe hyperlipidaemia or severe disorders of lipid metabolism characterized by hypertriglyceridaemia. Severe hyperglycaemia. Pathologically elevated plasma conc of Na, K, Mg, Ca &/or P. Premature neonates, infants & childn <2 yr.

Immediately stop infusion if any signs or symptoms of allergic reaction develop. Reports of pulmonary vascular precipitates causing pulmonary vascular embolism & resp distress; suspected blood stream precipitate; elevated liver enzymes & cholestasis; fat overload syndrome. Stop infusion if signs of resp distress occurs. Formation of precipitates or destabilization of the lipid emulsion could result in vascular occlusion. Correct severe water & electrolyte equilibration disorders, severe fluid overload states, & severe metabolic disorders prior to treatment initiation. Monitor water & electrolyte balance, serum osmolarity, serum triglycerides, acid/base balance, blood glucose, liver & kidney function tests, coagulation tests & blood count, including platelets, throughout treatment. Administration of amino acid soln may precipitate acute folate deficiency; daily intake of folic acid is recommended. Discontinue administration in case of extravasation. Use cautiously in patients w/ coagulation disorders & anaemia; metabolic acidosis, DM, hyperlipidaemia, amino acid metabolism disorders; increased osmolarity, adrenal insufficiency heart failure or pulmonary dysfunction. Risk of fluid shifts in malnourished patients. May interfere w/ certain laboratory tests (eg, bilirubin, lactate dehydrogenase, oxygen saturation, blood Hb) if the blood sample is taken before the lipids are eliminated. Concomitant use w/ ceftriaxone. Hepatic & renal insufficiency. Childn. Olimel N9E Do not administer through a peripheral vein. PeriOlimel N4E Monitor infusion site for local signs of thrombophlebitis.

Tachycardia; anorexia, hypertriglyceridemia; abdominal pain, diarrhoea, nausea; HTN.

Possibility of pseudoagglutination when administered simultaneously w/ blood through the same infusion tubing. Precipitation of ceftriaxone-Ca can occur when ceftriaxone is mixed w/ Ca-containing soln in the same IV administration line. Risk of hyperkalaemia w/ K-sparing diuretics (eg, amiloride, spironolactone, triamterene), ACE inhibitors, AIIA, tacrolimus or cyclosporine.

Parenteral Nutritional Products

B05BA10 - combinations ; Belongs to the class of solutions for parenteral nutrition used in I.V. solutions.

P₁S₁S₃